{"id":9012,"date":"2021-10-27T10:33:27","date_gmt":"2021-10-27T03:33:27","guid":{"rendered":"https:\/\/www.oucru.vn\/nghien-cuu-tai-dinh-vi-thuoc-cho-thay-tamoxifen-khong-co-ich-trong-viec-dieu-tri-viem-mang-nao-gay-tu-vong-do-nam\/"},"modified":"2021-10-27T10:33:27","modified_gmt":"2021-10-27T03:33:27","slug":"nghien-cuu-tai-dinh-vi-thuoc-cho-thay-tamoxifen-khong-co-ich-trong-viec-dieu-tri-viem-mang-nao-gay-tu-vong-do-nam","status":"publish","type":"post","link":"https:\/\/test.oucru.org\/index.php\/2021\/10\/27\/nghien-cuu-tai-dinh-vi-thuoc-cho-thay-tamoxifen-khong-co-ich-trong-viec-dieu-tri-viem-mang-nao-gay-tu-vong-do-nam\/","title":{"rendered":"Nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u t\u00c3\u00a1i \u00c4\u2018\u00e1\u00bb\u2039nh v\u00e1\u00bb\u2039 thu\u00e1\u00bb\u2018c cho th\u00e1\u00ba\u00a5y Tamoxifen kh\u00c3\u00b4ng c\u00c3\u00b3 \u00c3\u00adch trong vi\u00e1\u00bb\u2021c \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o g\u00c3\u00a2y t\u00e1\u00bb\u00ad vong do n\u00e1\u00ba\u00a5m"},"content":{"rendered":"<p><em><strong>Nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u t\u00c3\u00a1i \u00c4\u2018\u00e1\u00bb\u2039nh v\u00e1\u00bb\u2039 thu\u00e1\u00bb\u2018c cho m\u00e1\u00bb\u2122t d\u00e1\u00ba\u00a1ng vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o g\u00c3\u00a2y t\u00e1\u00bb\u00ad vong do n\u00e1\u00ba\u00a5m cho th\u00e1\u00ba\u00a5y Tamoxifen kh\u00c3\u00b4ng c\u00c3\u00b3 \u00c3\u00adch trong vi\u00e1\u00bb\u2021c \u00c4\u2018\u00e1\u00ba\u00a9y nhanh qu\u00c3\u00a1 tr\u00c3\u00acnh lo\u00e1\u00ba\u00a1i b\u00e1\u00bb\u008f nhi\u00e1\u00bb\u2026m n\u00e1\u00ba\u00a5m.<\/strong><\/em><\/p>\n<p>K\u00e1\u00ba\u00bft qu\u00e1\u00ba\u00a3 c\u00e1\u00bb\u00a7a th\u00e1\u00bb\u00ad nghi\u00e1\u00bb\u2021m l\u00c3\u00a2m s\u00c3\u00a0ng \u00c4\u2018\u00c6\u00b0\u00e1\u00bb\u00a3c c\u00c3\u00b4ng b\u00e1\u00bb\u2018 <a href=\"https:\/\/elifesciences.org\/articles\/68929\">tr\u00c3\u00aan eLife<\/a> g\u00e1\u00ba\u00a7n \u00c4\u2018\u00c3\u00a2y \u00c4\u2018\u00c3\u00a3 d\u00e1\u00ba\u00adp t\u00e1\u00ba\u00aft hy v\u00e1\u00bb\u008dng r\u00e1\u00ba\u00b1ng Tamoxifen c\u00c3\u00b3 th\u00e1\u00bb\u0192 t\u00c4\u0192ng kh\u00e1\u00ba\u00a3 n\u00c4\u0192ng s\u00e1\u00bb\u2018ng s\u00c3\u00b3t cho b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n m\u00e1\u00ba\u00afc m\u00e1\u00bb\u2122t d\u00e1\u00ba\u00a1ng vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o g\u00c3\u00a2y t\u00e1\u00bb\u00ad vong do n\u00e1\u00ba\u00a5m.<\/p>\n<p>Nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u cho th\u00e1\u00ba\u00a5y vi\u00e1\u00bb\u2021c th\u00c3\u00aam Tamoxifen v\u00c3\u00a0o ph\u00c3\u00a1c \u00c4\u2018\u00e1\u00bb\u201c \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 kh\u00c3\u00a1ng n\u00e1\u00ba\u00a5m ti\u00c3\u00aau chu\u00e1\u00ba\u00a9n kh\u00c3\u00b4ng gi\u00c3\u00bap \u00c4\u2018\u00e1\u00ba\u00a9y nhanh qu\u00c3\u00a1 tr\u00c3\u00acnh lo\u00e1\u00ba\u00a1i b\u00e1\u00bb\u008f nhi\u00e1\u00bb\u2026m n\u00e1\u00ba\u00a5m kh\u00e1\u00bb\u008fi d\u00e1\u00bb\u2039ch t\u00e1\u00bb\u00a7y s\u00e1\u00bb\u2018ng c\u00e1\u00bb\u00a7a nh\u00e1\u00bb\u00afng ng\u00c6\u00b0\u00e1\u00bb\u009di m\u00e1\u00ba\u00afc vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o. C\u00c3\u00b3 b\u00e1\u00ba\u00b1ng ch\u00e1\u00bb\u00a9ng cho th\u00e1\u00ba\u00a5y nhi\u00e1\u00bb\u0081u b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n g\u00e1\u00ba\u00b7p r\u00e1\u00bb\u2018i lo\u00e1\u00ba\u00a1n d\u00e1\u00ba\u00abn truy\u00e1\u00bb\u0081n trong tim khi d\u00c3\u00b9ng Tamoxifen, m\u00e1\u00ba\u00b7c d\u00c3\u00b9 c\u00e1\u00ba\u00a3 hai nh\u00c3\u00b3m nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u \u00c4\u2018\u00e1\u00bb\u0081u kh\u00c3\u00b4ng c\u00c3\u00b3 s\u00e1\u00bb\u00b1 kh\u00c3\u00a1c bi\u00e1\u00bb\u2021t v\u00e1\u00bb\u0081 t\u00e1\u00bb\u00b7 l\u00e1\u00bb\u2021 t\u00c3\u00a1c d\u00e1\u00bb\u00a5ng ph\u00e1\u00bb\u00a5 nghi\u00c3\u00aam tr\u00e1\u00bb\u008dng.<\/p>\n<p>Vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o do Cryptococcus l\u00c3\u00a0 nguy\u00c3\u00aan nh\u00c3\u00a2n g\u00c3\u00a2y t\u00e1\u00bb\u00ad vong h\u00c3\u00a0ng \u00c4\u2018\u00e1\u00ba\u00a7u \u00e1\u00bb\u0178 nh\u00e1\u00bb\u00afng ng\u00c6\u00b0\u00e1\u00bb\u009di nhi\u00e1\u00bb\u2026m HIV, nh\u00c6\u00b0ng c\u00c5\u00a9ng \u00e1\u00ba\u00a3nh h\u00c6\u00b0\u00e1\u00bb\u0178ng \u00c4\u2018\u00e1\u00ba\u00bfn nh\u00e1\u00bb\u00afng ng\u00c6\u00b0\u00e1\u00bb\u009di kh\u00c3\u00b4ng nhi\u00e1\u00bb\u2026m HIV, d\u00c3\u00b9 h\u00e1\u00bb\u008d c\u00c3\u00b3 suy gi\u00e1\u00ba\u00a3m mi\u00e1\u00bb\u2026n d\u00e1\u00bb\u2039ch hay kh\u00c3\u00b4ng. H\u00e1\u00ba\u00a7u h\u00e1\u00ba\u00bft c\u00c3\u00a1c tr\u00c6\u00b0\u00e1\u00bb\u009dng h\u00e1\u00bb\u00a3p nhi\u00e1\u00bb\u2026m \u00c4\u2018\u00e1\u00bb\u0081u do m\u00e1\u00bb\u2122t lo\u00e1\u00ba\u00a1i n\u00e1\u00ba\u00a5m c\u00c3\u00b3 t\u00c3\u00aan Cryptococcus neoformans (C. neoformans) v\u00c3\u00a0 x\u00e1\u00ba\u00a3y ra \u00e1\u00bb\u0178 nh\u00e1\u00bb\u00afng khu v\u00e1\u00bb\u00b1c nhi\u00e1\u00bb\u2021t \u00c4\u2018\u00e1\u00bb\u203ai, c\u00c3\u00b3 thu nh\u00e1\u00ba\u00adp th\u00e1\u00ba\u00a5p. Ph\u00c3\u00a1c \u00c4\u2018\u00e1\u00bb\u201c \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 ti\u00c3\u00aau chu\u00e1\u00ba\u00a9n v\u00c3\u00a0ng l\u00c3\u00a0 k\u00e1\u00ba\u00bft h\u00e1\u00bb\u00a3p ba lo\u00e1\u00ba\u00a1i thu\u00e1\u00bb\u2018c: ban \u00c4\u2018\u00e1\u00ba\u00a7u l\u00c3\u00a0 Flucytosine v\u00c3\u00a0 Amphotericin B, sau \u00c4\u2018\u00c3\u00b3 l\u00c3\u00a0 Fluconazole. Tuy nhi\u00c3\u00aan, ngay c\u00e1\u00ba\u00a3 khi d\u00c3\u00b9ng ph\u00c3\u00a1c \u00c4\u2018\u00e1\u00bb\u201c n\u00c3\u00a0y, m\u00e1\u00bb\u2122t ph\u00e1\u00ba\u00a7n ba b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n v\u00e1\u00ba\u00abn t\u00e1\u00bb\u00ad vong trong v\u00c3\u00b2ng 10 tu\u00e1\u00ba\u00a7n sau ch\u00e1\u00ba\u00a9n \u00c4\u2018o\u00c3\u00a1n. B\u00c3\u00aan c\u00e1\u00ba\u00a1nh \u00c4\u2018\u00c3\u00b3, Flucytosine g\u00e1\u00ba\u00b7p h\u00e1\u00ba\u00a1n ch\u00e1\u00ba\u00bf l\u00e1\u00bb\u203an v\u00e1\u00bb\u0081 t\u00c3\u00adnh s\u00e1\u00ba\u00b5n c\u00c3\u00b3 v\u00c3\u00a0 chi ph\u00c3\u00ad, ngh\u00c4\u00a9a l\u00c3\u00a0 thu\u00e1\u00bb\u2018c n\u00c3\u00a0y hi\u00e1\u00ba\u00bfm khi \u00c4\u2018\u00c6\u00b0\u00e1\u00bb\u00a3c s\u00e1\u00bb\u00ad d\u00e1\u00bb\u00a5ng \u00e1\u00bb\u0178 nh\u00e1\u00bb\u00afng n\u00c6\u00a1i c\u00c3\u00b3 g\u00c3\u00a1nh n\u00e1\u00ba\u00b7ng b\u00e1\u00bb\u2021nh t\u00e1\u00ba\u00adt cao nh\u00e1\u00ba\u00a5t.<\/p>\n<p>\u00e2\u20ac\u0153Tamoxifen th\u00e1\u00bb\u0192 hi\u00e1\u00bb\u2021n ho\u00e1\u00ba\u00a1t t\u00c3\u00adnh kh\u00c3\u00a1ng n\u00e1\u00ba\u00a5m ch\u00e1\u00bb\u2018ng l\u00e1\u00ba\u00a1i c\u00c3\u00a1c lo\u00e1\u00ba\u00a1i n\u00e1\u00ba\u00a5m men kh\u00c3\u00a1c nhau trong ph\u00c3\u00b2ng th\u00c3\u00ad nghi\u00e1\u00bb\u2021m; ch\u00c3\u00bang t\u00c3\u00b4i c\u00c5\u00a9ng \u00c4\u2018\u00c3\u00a3 cho th\u00e1\u00ba\u00a5y r\u00e1\u00ba\u00b1ng thu\u00e1\u00bb\u2018c c\u00c3\u00b3 th\u00e1\u00bb\u0192 ho\u00e1\u00ba\u00a1t \u00c4\u2018\u00e1\u00bb\u2122ng hi\u00e1\u00bb\u2021p \u00c4\u2018\u00e1\u00bb\u201cng v\u00e1\u00bb\u203ai Amphotericin \u00c4\u2018\u00e1\u00bb\u0192 kh\u00c3\u00a1ng 2\/3 s\u00e1\u00bb\u2018 ph\u00c3\u00a2n l\u00e1\u00ba\u00adp l\u00c3\u00a2m s\u00c3\u00a0ng c\u00e1\u00bb\u00a7a ch\u00e1\u00bb\u00a7ng Cryptococcus trong kho l\u00c6\u00b0u tr\u00e1\u00bb\u00af c\u00e1\u00bb\u00a7a ch\u00c3\u00bang t\u00c3\u00b4i. Ch\u00c3\u00bang ta hi\u00e1\u00bb\u0192u r\u00c3\u00b5 v\u00e1\u00bb\u0081 Tamoxifen, thu\u00e1\u00bb\u2018c kh\u00c3\u00b4ng c\u00c3\u00b3 b\u00e1\u00ba\u00b1ng s\u00c3\u00a1ng ch\u00e1\u00ba\u00bf, gi\u00c3\u00a1 th\u00c3\u00ac r\u00e1\u00ba\u00bb v\u00c3\u00a0 ph\u00e1\u00bb\u2022 bi\u00e1\u00ba\u00bfn r\u00e1\u00bb\u2122ng r\u00c3\u00a3i. Do \u00c4\u2018\u00c3\u00b3, n\u00c3\u00b3 l\u00c3\u00a0 \u00e1\u00bb\u00a9ng c\u00e1\u00bb\u00ad vi\u00c3\u00aan \u00c4\u2018\u00e1\u00ba\u00a7y h\u00e1\u00bb\u00a9a h\u00e1\u00ba\u00b9n cho vi\u00e1\u00bb\u2021c \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o do Cryptococcus\u00e2\u20ac\u009d, B\u00c3\u00a1c s\u00c4\u00a9 Nguy\u00e1\u00bb\u2026n Th\u00e1\u00bb\u2039 Th\u00e1\u00bb\u00a7y Ng\u00c3\u00a2n, \u00c4\u2018\u00e1\u00bb\u201cng T\u00c3\u00a1c gi\u00e1\u00ba\u00a3 th\u00e1\u00bb\u00a9 nh\u00e1\u00ba\u00a5t v\u00c3\u00a0 B\u00c3\u00a1c s\u00c4\u00a9 l\u00c3\u00a2m s\u00c3\u00a0ng t\u00e1\u00ba\u00a1i Khoa B\u00e1\u00bb\u2021nh Nhi\u00e1\u00bb\u2021t \u00c4\u2018\u00e1\u00bb\u203ai, B\u00e1\u00bb\u2021nh vi\u00e1\u00bb\u2021n Ch\u00e1\u00bb\u00a3 R\u00e1\u00ba\u00aby v\u00c3\u00a0 \u00c4\u0090\u00c6\u00a1n v\u00e1\u00bb\u2039 Nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u L\u00c3\u00a2m s\u00c3\u00a0ng \u00c4\u0090\u00e1\u00ba\u00a1i h\u00e1\u00bb\u008dc Oxford (OUCRU), Th\u00c3\u00a0nh ph\u00e1\u00bb\u2018 H\u00e1\u00bb\u201c Ch\u00c3\u00ad Minh, Vi\u00e1\u00bb\u2021t Nam, cho bi\u00e1\u00ba\u00bft.<\/p>\n<p>\u00e2\u20ac\u0153Ch\u00c3\u00bang t\u00c3\u00b4i \u00c4\u2018\u00c3\u00a3 thi\u00e1\u00ba\u00bft k\u00e1\u00ba\u00bf m\u00e1\u00bb\u2122t th\u00e1\u00bb\u00ad nghi\u00e1\u00bb\u2021m ng\u00e1\u00ba\u00abu nhi\u00c3\u00aan \u00c4\u2018\u00e1\u00bb\u0192 x\u00c3\u00a1c \u00c4\u2018\u00e1\u00bb\u2039nh xem vi\u00e1\u00bb\u2021c s\u00e1\u00bb\u00ad d\u00e1\u00bb\u00a5ng k\u00e1\u00ba\u00bft h\u00e1\u00bb\u00a3p c\u00c3\u00a1c lo\u00e1\u00ba\u00a1i thu\u00e1\u00bb\u2018c n\u00c3\u00a0y c\u00c3\u00b3 th\u00e1\u00bb\u0192 c\u00e1\u00ba\u00a3i thi\u00e1\u00bb\u2021n t\u00e1\u00bb\u2018c \u00c4\u2018\u00e1\u00bb\u2122 kh\u00e1\u00bb\u008fi nhi\u00e1\u00bb\u2026m n\u00e1\u00ba\u00a5m Cryptococcus hay kh\u00c3\u00b4ng &#8211; \u00e1\u00bb\u0178 c\u00e1\u00ba\u00a3 b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o c\u00c3\u00b3 HIV v\u00c3\u00a0 b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o kh\u00c3\u00b4ng c\u00c3\u00b3 HIV\u00e2\u20ac\u009d, Ti\u00e1\u00ba\u00bfn s\u00c4\u00a9 L\u00c3\u00aa Thanh Ho\u00c3\u00a0ng Nh\u00e1\u00ba\u00adt, \u00c4\u2018\u00e1\u00bb\u201cng T\u00c3\u00a1c gi\u00e1\u00ba\u00a3 th\u00e1\u00bb\u00a9 nh\u00e1\u00ba\u00a5t v\u00c3\u00a0 Chuy\u00c3\u00aan gia th\u00e1\u00bb\u2018ng k\u00c3\u00aa sinh h\u00e1\u00bb\u008dc t\u00e1\u00ba\u00a1i OUCRU, cho bi\u00e1\u00ba\u00bft th\u00c3\u00aam.<\/p>\n<p>Th\u00e1\u00bb\u00ad nghi\u00e1\u00bb\u2021m c\u00c3\u00b3 s\u00e1\u00bb\u00b1 tham gia c\u00e1\u00bb\u00a7a 50 b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n &#8211; 40 ng\u00c6\u00b0\u00e1\u00bb\u009di nhi\u00e1\u00bb\u2026m HIV v\u00c3\u00a0 10 ng\u00c6\u00b0\u00e1\u00bb\u009di kh\u00c3\u00b4ng nhi\u00e1\u00bb\u2026m. Trong s\u00e1\u00bb\u2018 c\u00c3\u00a1c b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n, 24 b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n \u00c4\u2018\u00c6\u00b0\u00e1\u00bb\u00a3c ch\u00e1\u00bb\u2030 \u00c4\u2018\u00e1\u00bb\u2039nh ph\u00c3\u00a1c \u00c4\u2018\u00e1\u00bb\u201c \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 ch\u00e1\u00bb\u2018ng n\u00e1\u00ba\u00a5m ti\u00c3\u00aau chu\u00e1\u00ba\u00a9n, g\u00e1\u00bb\u201cm Amphotericin B v\u00c3\u00a0 Fluconazole, c\u00e1\u00bb\u2122ng th\u00c3\u00aam Tamoxifen, v\u00c3\u00a0 26 ng\u00c6\u00b0\u00e1\u00bb\u009di ch\u00e1\u00bb\u2030 \u00c4\u2018\u00c6\u00b0\u00e1\u00bb\u00a3c ch\u00e1\u00bb\u2030 \u00c4\u2018\u00e1\u00bb\u2039nh ph\u00c3\u00a1c \u00c4\u2018\u00e1\u00bb\u201c \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 ch\u00e1\u00bb\u2018ng n\u00e1\u00ba\u00a5m ti\u00c3\u00aau chu\u00e1\u00ba\u00a9n. Nh\u00c3\u00b3m nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u \u00c4\u2018\u00c3\u00a3 \u00c4\u2018o Ho\u00e1\u00ba\u00a1t \u00c4\u2018\u00e1\u00bb\u2122ng Di\u00e1\u00bb\u2021t n\u00e1\u00ba\u00a5m Ban \u00c4\u2018\u00e1\u00ba\u00a7u (Early Fungicidal Activity &#8211; EFA) c\u00e1\u00bb\u00a7a c\u00e1\u00ba\u00a3 hai nh\u00c3\u00b3m &#8211; t\u00e1\u00bb\u00a9c l\u00c3\u00a0 \u00c4\u2018o xem l\u00c6\u00b0\u00e1\u00bb\u00a3ng C. neoformans trong d\u00e1\u00bb\u2039ch t\u00e1\u00bb\u00a7y s\u00e1\u00bb\u2018ng c\u00e1\u00bb\u00a7a b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n gi\u00e1\u00ba\u00a3m nhanh nh\u00c6\u00b0 th\u00e1\u00ba\u00bf n\u00c3\u00a0o trong hai tu\u00e1\u00ba\u00a7n sau \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039.<\/p>\n<p>D\u00e1\u00bb\u00b1a tr\u00c3\u00aan c\u00c3\u00a1c th\u00c3\u00ad nghi\u00e1\u00bb\u2021m tr\u00c6\u00b0\u00e1\u00bb\u203ac \u00c4\u2018\u00c3\u00b3 c\u00e1\u00bb\u00a7a m\u00c3\u00acnh, nh\u00c3\u00b3m \u00c4\u2018\u00c3\u00a3 hy v\u00e1\u00bb\u008dng nh\u00e1\u00bb\u00afng b\u00e1\u00bb\u2021nh nh\u00c3\u00a2n \u00c4\u2018\u00c3\u00a3 nh\u00e1\u00ba\u00adn Tamoxifen trong ph\u00c3\u00a1c \u00c4\u2018\u00e1\u00bb\u201c \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 ch\u00e1\u00bb\u2018ng n\u00e1\u00ba\u00a5m s\u00e1\u00ba\u00bd c\u00c3\u00b3 EFA t\u00e1\u00bb\u2018t h\u00c6\u00a1n. Tuy nhi\u00c3\u00aan, h\u00e1\u00bb\u008d kh\u00c3\u00b4ng ph\u00c3\u00a1t hi\u00e1\u00bb\u2021n th\u00e1\u00ba\u00a5y s\u00e1\u00bb\u00b1 kh\u00c3\u00a1c bi\u00e1\u00bb\u2021t n\u00c3\u00a0o v\u00e1\u00bb\u0081 EFA \u00e1\u00bb\u0178 hai nh\u00c3\u00b3m.<\/p>\n<p>\u00c4\u0090i\u00e1\u00bb\u0192m kh\u00c3\u00a1c bi\u00e1\u00bb\u2021t duy nh\u00e1\u00ba\u00a5t gi\u00e1\u00bb\u00afa hai nh\u00c3\u00b3m \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 l\u00c3\u00a0 nh\u00c3\u00b3m d\u00c3\u00b9ng Tamoxifen c\u00c3\u00b3 t\u00c3\u00acnh tr\u00e1\u00ba\u00a1ng t\u00c4\u0192ng \u00c4\u2018\u00e1\u00bb\u2122c t\u00c3\u00adnh trong tim. C\u00c3\u00a1c nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u trong ph\u00c3\u00b2ng th\u00c3\u00ad nghi\u00e1\u00bb\u2021m \u00c4\u2018\u00c3\u00a3 ch\u00e1\u00bb\u2030 ra r\u00e1\u00ba\u00b1ng c\u00e1\u00ba\u00a7n s\u00e1\u00bb\u00ad d\u00e1\u00bb\u00a5ng li\u00e1\u00bb\u0081u Tamoxifen cao g\u00e1\u00ba\u00a5p 5\u00e2\u20ac\u201c10 l\u00e1\u00ba\u00a7n so v\u00e1\u00bb\u203ai li\u00e1\u00bb\u0081u \u00c4\u2018\u00c6\u00b0\u00e1\u00bb\u00a3c s\u00e1\u00bb\u00ad d\u00e1\u00bb\u00a5ng th\u00c6\u00b0\u00e1\u00bb\u009dng xuy\u00c3\u00aan trong \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 ung th\u00c6\u00b0 v\u00c3\u00ba \u00c4\u2018\u00e1\u00bb\u0192 c\u00c3\u00b3 t\u00c3\u00a1c d\u00e1\u00bb\u00a5ng kh\u00c3\u00a1ng n\u00e1\u00ba\u00a5m. Nh\u00c6\u00b0ng li\u00e1\u00bb\u0081u l\u00c6\u00b0\u00e1\u00bb\u00a3ng Tamoxifen cao c\u00c3\u00b3 th\u00e1\u00bb\u0192 g\u00c3\u00a2y h\u00e1\u00bb\u2122i ch\u00e1\u00bb\u00a9ng QT k\u00c3\u00a9o d\u00c3\u00a0i cho tim \u00e2\u20ac\u201c h\u00e1\u00bb\u2122i ch\u00e1\u00bb\u00a9ng QT k\u00c3\u00a9o d\u00c3\u00a0i l\u00c3\u00a0 m\u00e1\u00bb\u2122t b\u00e1\u00ba\u00a5t th\u00c6\u00b0\u00e1\u00bb\u009dng c\u00c3\u00b3 th\u00e1\u00bb\u0192 g\u00c3\u00a2y ng\u00e1\u00bb\u00abng tim. Trong nh\u00c3\u00b3m d\u00c3\u00b9ng Tamoxifen c\u00e1\u00bb\u00a7a nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u n\u00c3\u00a0y, c\u00c3\u00b3 m\u00e1\u00bb\u2122t tr\u00c6\u00b0\u00e1\u00bb\u009dng h\u00e1\u00bb\u00a3p \u00c4\u2018\u00e1\u00bb\u2122t t\u00e1\u00bb\u00ad, m\u00e1\u00ba\u00b7c d\u00c3\u00b9 t\u00c3\u00acnh tr\u00e1\u00ba\u00a1ng t\u00e1\u00bb\u00ad vong di\u00e1\u00bb\u2026n ra sau kho\u00e1\u00ba\u00a3ng th\u00e1\u00bb\u009di gian d\u00c3\u00b9ng Tamoxifen v\u00c3\u00a0 kh\u00c3\u00b4ng li\u00c3\u00aan quan \u00c4\u2018\u00e1\u00ba\u00bfn nh\u00e1\u00bb\u2039p tim b\u00e1\u00ba\u00a5t th\u00c6\u00b0\u00e1\u00bb\u009dng.<\/p>\n<p><a href=\"https:\/\/www.oucru.org\/en\/jeremy-day\/\">Gi\u00c3\u00a1o s\u00c6\u00b0 Jeremy Day<\/a>, T\u00c3\u00a1c gi\u00e1\u00ba\u00a3 c\u00e1\u00ba\u00a5p cao v\u00c3\u00a0 Tr\u00c6\u00b0\u00e1\u00bb\u0178ng nh\u00c3\u00b3m Nh\u00c3\u00b3m Nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u Nhi\u00e1\u00bb\u2026m tr\u00c3\u00b9ng Th\u00e1\u00ba\u00a7n kinh Trung \u00c6\u00b0\u00c6\u00a1ng v\u00c3\u00a0 HIV c\u00e1\u00bb\u00a7a OUCRU, v\u00c3\u00a0 Gi\u00c3\u00a1o s\u00c6\u00b0 v\u00e1\u00bb\u0081 B\u00e1\u00bb\u2021nh truy\u00e1\u00bb\u0081n nhi\u00e1\u00bb\u2026m t\u00e1\u00ba\u00a1i Trung t\u00c3\u00a2m Y h\u00e1\u00bb\u008dc Nhi\u00e1\u00bb\u2021t \u00c4\u2018\u00e1\u00bb\u203ai v\u00c3\u00a0 S\u00e1\u00bb\u00a9c kh\u00e1\u00bb\u008fe To\u00c3\u00a0n c\u00e1\u00ba\u00a7u, \u00c4\u0090\u00e1\u00ba\u00a1i h\u00e1\u00bb\u008dc Oxford, V\u00c6\u00b0\u00c6\u00a1ng qu\u00e1\u00bb\u2018c Anh, k\u00e1\u00ba\u00bft lu\u00e1\u00ba\u00adn: \u00e2\u20ac\u0153M\u00e1\u00ba\u00b7c d\u00c3\u00b9 c\u00c3\u00b3 t\u00c3\u00a1c d\u00e1\u00bb\u00a5ng ch\u00e1\u00bb\u2018ng Cryptococcus v\u00c3\u00a0 c\u00c3\u00b3 kh\u00e1\u00ba\u00a3 n\u00c4\u0192ng ph\u00e1\u00bb\u2018i h\u00e1\u00bb\u00a3p v\u00e1\u00bb\u203ai c\u00c3\u00a1c thu\u00e1\u00bb\u2018c kh\u00c3\u00a1c, Tamoxifen kh\u00c3\u00b4ng l\u00c3\u00a0m t\u00c4\u0192ng t\u00e1\u00bb\u2018c \u00c4\u2018\u00e1\u00bb\u2122 lo\u00e1\u00ba\u00a1i n\u00e1\u00ba\u00a5m men kh\u00e1\u00bb\u008fi d\u00e1\u00bb\u2039ch t\u00e1\u00bb\u00a7y s\u00e1\u00bb\u2018ng \u00e1\u00bb\u0178 nh\u00e1\u00bb\u00afng ng\u00c6\u00b0\u00e1\u00bb\u009di vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o v\u00c3\u00a0 kh\u00e1\u00ba\u00a3 n\u00c4\u0192ng cao l\u00c3\u00a0 kh\u00c3\u00b4ng mang l\u00e1\u00ba\u00a1i l\u00e1\u00bb\u00a3i \u00c3\u00adch l\u00c3\u00a2m s\u00c3\u00a0ng\u00e2\u20ac\u009d.<\/p>\n<p>\u00e2\u20ac\u0153K\u00e1\u00ba\u00bft qu\u00e1\u00ba\u00a3 c\u00e1\u00bb\u00a7a ch\u00c3\u00bang t\u00c3\u00b4i cho th\u00e1\u00ba\u00a5y t\u00e1\u00ba\u00a7m quan tr\u00e1\u00bb\u008dng c\u00e1\u00bb\u00a7a c\u00c3\u00a1c th\u00e1\u00bb\u00ad nghi\u00e1\u00bb\u2021m quy m\u00c3\u00b4 nh\u00e1\u00bb\u008f nh\u00c6\u00b0 th\u00e1\u00ba\u00bf n\u00c3\u00a0y trong vi\u00e1\u00bb\u2021c \u00c4\u2018\u00c3\u00a1nh gi\u00c3\u00a1 nhanh c\u00c3\u00a1c lo\u00e1\u00ba\u00a1i thu\u00e1\u00bb\u2018c c\u00c3\u00b3 th\u00e1\u00bb\u0192 t\u00c3\u00a1i \u00c4\u2018\u00e1\u00bb\u2039nh v\u00e1\u00bb\u2039\/t\u00c3\u00a1i s\u00e1\u00bb\u00ad d\u00e1\u00bb\u00a5ng v\u00c3\u00a0 gi\u00c3\u00bap ti\u00e1\u00ba\u00bft ki\u00e1\u00bb\u2021m th\u00e1\u00bb\u009di gian v\u00c3\u00a0 chi ph\u00c3\u00ad cho nh\u00e1\u00bb\u00afng nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u l\u00c3\u00a2m s\u00c3\u00a0ng l\u00e1\u00bb\u203an h\u00c6\u00a1n m\u00c3\u00a0 c\u00c3\u00b3 kh\u00e1\u00ba\u00a3 n\u00c4\u0192ng kh\u00c3\u00b4ng th\u00c3\u00a0nh c\u00c3\u00b4ng. Tuy nhi\u00c3\u00aan, \u00c4\u2018i\u00e1\u00bb\u0081u n\u00c3\u00a0y c\u00c3\u00b3 ngh\u00c4\u00a9a l\u00c3\u00a0 ch\u00c3\u00bang ta v\u00e1\u00ba\u00abn c\u00e1\u00ba\u00a7n nhanh ch\u00c3\u00b3ng ph\u00c3\u00a1t tri\u00e1\u00bb\u0192n c\u00c3\u00a1c lo\u00e1\u00ba\u00a1i thu\u00e1\u00bb\u2018c \u00c4\u2018\u00e1\u00ba\u00b7c tr\u00e1\u00bb\u2039 Cryptococcus m\u00e1\u00bb\u203ai, v\u00c3\u00a0 c\u00c5\u00a9ng c\u00e1\u00ba\u00a7n \u00c4\u2018\u00e1\u00ba\u00a3m b\u00e1\u00ba\u00a3o r\u00e1\u00ba\u00b1ng ng\u00c6\u00b0\u00e1\u00bb\u009di b\u00e1\u00bb\u2021nh c\u00c3\u00b3 th\u00e1\u00bb\u0192 ti\u00e1\u00ba\u00bfp c\u00e1\u00ba\u00adn c\u00c3\u00a1c ph\u00c6\u00b0\u00c6\u00a1ng ph\u00c3\u00a1p \u00c4\u2018i\u00e1\u00bb\u0081u tr\u00e1\u00bb\u2039 hi\u00e1\u00bb\u2021n c\u00c3\u00b3 v\u00e1\u00bb\u203ai gi\u00c3\u00a1 ph\u00e1\u00ba\u00a3i ch\u00c4\u0192ng\u00e2\u20ac\u009d.<\/p>\n<hr \/>\n<p>\u00c4\u0090\u00e1\u00bb\u0192 bi\u00e1\u00ba\u00bft th\u00c3\u00aam th\u00c3\u00b4ng tin, vui l\u00c3\u00b2ng li\u00c3\u00aan h\u00e1\u00bb\u2021:\u00c2\u00a0Communications@oucru.org<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nghi\u00c3\u00aan c\u00e1\u00bb\u00a9u t\u00c3\u00a1i \u00c4\u2018\u00e1\u00bb\u2039nh v\u00e1\u00bb\u2039 thu\u00e1\u00bb\u2018c cho m\u00e1\u00bb\u2122t d\u00e1\u00ba\u00a1ng vi\u00c3\u00aam m\u00c3\u00a0ng n\u00c3\u00a3o g\u00c3\u00a2y t\u00e1\u00bb\u00ad vong do n\u00e1\u00ba\u00a5m cho th\u00e1\u00ba\u00a5y Tamoxifen kh\u00c3\u00b4ng c\u00c3\u00b3 \u00c3\u00adch trong vi\u00e1\u00bb\u2021c \u00c4\u2018\u00e1\u00ba\u00a9y nhanh qu\u00c3\u00a1 tr\u00c3\u00acnh lo\u00e1\u00ba\u00a1i b\u00e1\u00bb\u008f nhi\u00e1\u00bb\u2026m n\u00e1\u00ba\u00a5m. K\u00e1\u00ba\u00bft qu\u00e1\u00ba\u00a3 c\u00e1\u00bb\u00a7a th\u00e1\u00bb\u00ad nghi\u00e1\u00bb\u2021m l\u00c3\u00a2m s\u00c3\u00a0ng \u00c4\u2018\u00c6\u00b0\u00e1\u00bb\u00a3c c\u00c3\u00b4ng b\u00e1\u00bb\u2018 tr\u00c3\u00aan eLife g\u00e1\u00ba\u00a7n \u00c4\u2018\u00c3\u00a2y \u00c4\u2018\u00c3\u00a3 d\u00e1\u00ba\u00adp t\u00e1\u00ba\u00aft hy v\u00e1\u00bb\u008dng r\u00e1\u00ba\u00b1ng Tamoxifen c\u00c3\u00b3 [&hellip;]<\/p>\n","protected":false},"author":28,"featured_media":9781,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[229],"tags":[],"class_list":["post-9012","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/posts\/9012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/users\/28"}],"replies":[{"embeddable":true,"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/comments?post=9012"}],"version-history":[{"count":0,"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/posts\/9012\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/media\/9781"}],"wp:attachment":[{"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/media?parent=9012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/categories?post=9012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/test.oucru.org\/index.php\/wp-json\/wp\/v2\/tags?post=9012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}